Institut für Pathologie der Tierärztlichen Hochschule Hannover, Bünteweg 17, D‐3000 Hannover 71, Germany. (2)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover. Pathogenesis and immunopathology of systemic and nervous canine distemper. (3)3 Institut für Pathologie der Stiftung Tieraerztliche Hochschule Hannover, Hannover, Germany. In acute and subacute CDE, a plaque-associated CD44 up-regulation is found that parallels astrocyte activation. Yang J, Li X, Cao YH, Pokharel K, Hu XJ, Chen ZH, Xu SS, Peippo J, Honkatukia M, Kantanen J, Li MH. A. Navarro Camarro. It is often referred to as TiHo by its staff and students. Silva LM, Baums CG, Rehm T, Wisselink HJ, Goethe R, Valentin-Weigand P. Vet Microbiol. Studies on pathogenesis as well as vaccine trials have focused on serotype 2 strains, which are worldwide the most prevalent among invasive isolates. This site needs JavaScript to work properly. Acta Neuropathol.  |  Corresponding Author . The present review decribes the role of CD44 antigen (CD44), the principle cell surface receptor for hyaluronate and extracellular matrix (ECM) processing enzymes (matrix metalloproteinases [MMPs]) and their inhibitors (TIMPs) in the pathogenesis of demyelination. Meurer M, Öhlmann S, Bonilla MC, Valentin-Weigand P, Beineke A, Hennig-Pauka I, Schwerk C, Schroten H, Baums CG, Köckritz-Blickwede MV, de Buhr N. Int J Mol Sci. Interestingly, expression of MRP within meningitis lesions was demonstrated for both pathotypes via immunohistochemistry. Streptococcus (S.) suis is an invasive porcine pathogen causing meningitis, septicemia, arthritis and other diseases. Beineke A, Puff C, Seehusen F, Baumgärtner W. Vet Immunol Immunopathol. Please enable it to take advantage of the complete set of features! In chronic lesions, CD44 expression declines together with the number of glial fibrillary acidic protein (GFAP) positive astrocytes. PMID: 12016561 DOI: 10.1055/s-2002-30116 Abstract The mode of action of probiotics is still incompletely understood. Gregor Warnecke Institut für Herz-, Thorax-, Transplantations- und Gefäßchirurgie Medizinische Hochschule Hannover 1. Fragen der Diagnostik: Geschäftszimmer, Tel.-Nr. Center for Systems Neuroscience, Stiftung Tierärztliche Hochschule Hannover, Medizinische Hochschule Hannover, ... Bedeutung für die molekulare Pathologie der Spinalen Muskelatrophie. Streptococcus (S.) suis is an invasive porcine pathogen causing meningitis, septicemia, arthritis and other diseases. 1 Klinik für kleine Klauentiere, forensische Medizin und Ambulatorische Klinik, Stiftung Tierärztliche Hochschule Hannover › Author Affiliations. However, histological screenings of these animals revealed pathological lesions, such as mild focal suppurative meningitis. Hannover und Umgebung, Deutschland Scientific Assistant at the Institute for Experimental Pathology of the Medical School Hannover (Director: Professor Dr. U. Mohr). Up-regulation of the hyaluronate receptor CD44 in canine distemper demyelinated plaques. 1 Institut für Pathologie, Tierärztliche Hochschule Hannover, Germany. NLM 2009 Nov 18;139(3-4):310-7. doi: 10.1016/j.vetmic.2009.06.024. Search for more papers by this author. J. Pohlenz. Lempp C, Spitzbarth I, Puff C, Cana A, Kegler K, Techangamsuwan S, Baumgärtner W, Seehusen F. Viruses. Thus, intravenous application of this serotype 9 strain is required to evaluate heterologous protection in the course of vaccine development based on serotype 2 strains in the future. NLM Andreas Beineke Institut für Pathologie Tierärztliche Hochschule Hannover Prof. Dr. med. In contrast to the virulent serotype 2 strain, the serotype 9 strain did not cause disease with clinical manifestations after intranasal administration. Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations. The University of Veterinary Medicine Hanover (German: Tierärztliche Hochschule Hannover, TiHo) is a university in Hanover and one of the five facilities for veterinary medicine in Germany, and the only one that remains independent. Prevention and treatment information (HHS). Epub 2009 May 18. The objective of this study was to determine the virulence of an MRP* SLY+ serotype 9 S. suis strain in comparison to an MRP+ EF+ SLY+ serotype 2 strain. Tenenbaum T, Asmat TM, Seitz M, Schroten H, Schwerk C. Future Microbiol. New aspects of the pathogenesis of canine distemper leukoencephalitis. NIH Clipboard, Search History, and several other advanced features are temporarily unavailable. Zhao ZQ, Wang LJ, Sun XW, Zhang JJ, Zhao YJ, Na RS, Zhang JH. (1)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, Hannover, Germany. 2014 Jul 2;6(7):2571-601. doi: 10.3390/v6072571. (2)2 Tieraerztliche Gemeinschaftspraxis Dres. doi: 10.1371/journal.pone.0152675. Universität Hannover, 2007. Search Google Scholar for this author, R. Müller-Peddinghaus. Institute of Pathology, Section of Immunopathology and Institute of Virology, School of Veterinary Medicine, Hannover. Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis. Epub 2005 Aug 25. Medizinische Hochschule Hannover, 2006. Publication History. 2019 Feb;122(2):172-186. doi: 10.1038/s41437-018-0090-1. Tierärztliche Hochschule Hannover Prof. Dr. med. Trends Microbiol. Further Information. vet. vet. COVID-19 is an emerging, rapidly evolving situation. HHS Epub 2016 Jun 30. (4)4 Klinik für Heimtiere, Reptilien, Zier- und Wildvoegel, Stiftung Tieraerztliche Hochschule, Hannover… Tierärztliche Hochschule Hannover Population and molecular genetic analyses of persistent right aortic arch and primary cataracts in the German Pinscher INAUGURAL-DISSERTATION zur Erlangung des Grades einer Doktorin der Veterinärmedizin - Doctor medicinae veterinariae – (Dr. med. 6 Kliniken, 19 Institute, 3 Fachgebiete und 3 Außenstellen gehören zur Stiftung Tierärztliche Hochschule Hannover. Institut für Pathologie, Tierärztliche Hochschule, Bunteweg 17, D‐30559 Hannover, Germany. USA.gov. Institut für Pathologie, Tierärztliche Hochschule Hannover › Author Affiliations › Further Information. Bacteriological culture and immunohistochemistry of the brain confirmed association with the S. suis challenge strains in all cases with clinical manifestations. (1)Institut für Pathologie, Tierärztliche Hochschule Hannover, 30559 Hannover, Germany. 2009 Jan 15;127(1-2):1-18. doi: 10.1016/j.vetimm.2008.09.023. Porcine Health Manag. Microarray analysis reveals gene and microRNA signatures in diabetic kidney disease. Author information: (1)Klinik für Rinder, Stiftung Tierärztliche Hochschule Hannover. Stiftung Tierärztliche Hochschule Hannover.  |  HHS Centre National des Listeria, Institut de Microbiologie, CHUV, CH‐19 Sud 1011, Lausanne, Switzerland . J. University Overview Founded in 1778, Tierärztliche Hochschule Hannover (University of Veterinary Medicine Hannover) is a non-profit public higher-education institution located in the urban setting of the large city of Hannover (population range of 500,000-1,000,000 inhabitants), Lower Saxony. vet. (3)Zentrum für Systemische Neurowissenschaften Hannover, ZSN. Andrea Düngelhoef, Sophie Gschaider, Jana Seele, Nadine Büttner, and Christoph Hirche are acknowledged for their excellent work during their practicals. Epub 2003 Aug 15. Role of Bacterial and Host DNases on Host-Pathogen Interaction during, A critical review speculating on the protective efficacies of autogenous, From Stable to Lab-Investigating Key Factors for Sudden Deaths Caused by, Vaccination with the immunoglobulin M-degrading enzyme of. vorgelegt von Julia Menzel Stuttgart Hannover 2010 . Dr. med. Clinical examination revealed a 15 × 20 × 15 cm firm … eCollection 2016. Willemse N, van der Ark KCH, Stockhofe-Zurwieden N, Smith H, Picavet DI, van Solt-Smits C, Wisselink HJ, Schultsz C, de Greeff A. Sci Rep. 2019 Oct 28;9(1):15429. doi: 10.1038/s41598-019-51576-0. Epub 2009 Jun 21.  |  2020 May 6;6:12. doi: 10.1186/s40813-020-00150-6. Clinical manifestations related to meningitis, arthritis and serositis could be induced by intravenous application of this serotype 9 strain. The principal histological findings were hyperkeratosis and epidermal hyperplasia. Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States. Stiftung Tierärztliche Hochschule Hannover. eCollection 2019 Dec 10. Transcriptome analysis of the Capra hircus ovary. USA.gov. Shen M, Di G, Li M, Fu J, Dai Q, Miao X, Huang M, You W, Ke C. Sci Rep. 2018 Apr 19;8(1):6269. doi: 10.1038/s41598-018-24645-z. Research topics. Intranasal immunization with a live Streptococcus suis isogenic ofs mutant elicited suilysin-neutralization titers but failed to induce opsonizing antibodies and protection. 2000 Feb;99(2):138-46. doi: 10.1007/pl00007417. Mol Med Rep. 2018 Feb;17(2):2161-2168. doi: 10.3892/mmr.2017.8177. Friederike Döring: Die intrazelluläre Lokalisation von Isoformen des Fibroblastenwachstumsfaktors – 2 (FGF-2). Abteilung für Experimentelle Pathologie, Dr. Karl Thomae GmbH, Biberach/Riß, und Institut für Pathologie, Abteilung für Immunpathologie, Tierärztliche Hochschule Hannover, Hannover, BRD See all articles by this author. 2019 Oct 10;3:100046. doi: 10.1016/j.jvacx.2019.100046. In this phase, a decrease of MMP and TIMP expressions apart from MMP-11, -12, and -13 is obvious. PLoS One. Arwid Daugschies Institut für Parasitologie Veterinärmedizinische Fakultät der Universität Leipzig 2. We are a leader in research, teaching and services in veterinary medicine and train young scientists in all areas of veterinary science. eCollection 2020. Experimental intranasal and intravenous infections of 7-8 weeks old SPF piglets were investigated with regard to clinic and pathology. Rieckmann K, Seydel A, Klose K, Alber G, Baums CG, Schütze N. Vaccine X. Would you like email updates of new search results? andreas.beineke@tiho-hannover.de Harbor porpoises from the North and Baltic Seas exhibit a higher incidence of bacterial infections compared to whales from less polluted arctic waters. Ligation of CD44 in the early phase may induce chemokines and cytokines and hence initiate and perpetuate the inflammatory process. Save as PDF. 2 Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, M. Ganter. Alldinger S, Fonfara S, Kremmer E, Baumgärtner W. Acta Neuropathol. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.  |  Doctoral student . 2009 Dec 15;132(2-4):135-45. doi: 10.1016/j.vetimm.2009.05.009. The working group „Behavioural ecology and conservation genetics“ aims to understand the factors, that drive and influence the evolution of social structures, the demographic composition, ecological niche construction, distribution, connectivity and the survival of populations. Miao Q, Baumgärtner W, Failing K, Alldinger S. Acta Neuropathol. Toward Understanding the Genetic Basis of Yak Ovary Reproduction: A Characterization and Comparative Analyses of Estrus Ovary Transcriptiome in Yak and Cattle. Gutachten: Prof. Dr. med. The skin lesions were divided into four macroscopic groups: scaling (group I, n = 5), hyperkeratotic and hyperplastic plaque‐like lesions (group II, n = 14), nodular skin masses (group III, n = 16) and verrucous skin lesions (group IV, n = 2).  |  Proteomics Studies on the three Larval Stages of Development and Metamorphosis of Babylonia areolata. Corresponding Author. To study the interactions between probiotic micro-organisms and the host their effects on morphology and mucins of the intestinal mucosa were investigated. NCI CPTC Antibody Characterization Program. COVID-19 is an emerging, rapidly evolving situation. Corresponding Author. eCollection 2015. Likewise, MMPs and TIMPs are prominently up-regulated in these lesions and are expressed mostly by astrocytes and microglia. PLoS One. Institut für Pathologie, Tierärztliche Hochschule Hannover, Peter Wohlsein. Dr. med. Canine distemper virus (CDV) belongs to the genus Morbillivirus of the Paramyxoviridae family. Institut für Pathologie Tierärztliche Hochschule Hannover PD Dr. med. In conclusion, this study demonstrates that MRP* SLY+ serotype 9 strains are less virulent for growers than MRP+ EF+ SLY+ serotype 2 strains. 2020 Jul 25;21(15):5289. doi: 10.3390/ijms21155289. "Perfect place to start a veterinary career" NIH The University of Veterinary Medicine Hannover, Foundation (TiHo) is a nationally and internationally recognized institution of higher education known for its excellence in veterinary science and its interdisciplinary focus. Beyerbach (Stiftung Tierärztliche Hochschule Hannover, Hannover, Germany) kindly provided support in statistical analysis. 2019 Nov 20;8(4):249. doi: 10.3390/pathogens8040249. This site needs JavaScript to work properly. Search for more papers by this author. Carlos Hermosilla Institut für Parasitologie Please enable it to take advantage of the complete set of features! Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent.  |  Vet Immunol Immunopathol. Biological activities of suilysin: role in Streptococcus suis pathogenesis. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.1371/journal.pone.0121586. This page... Print this page. 2005 Oct;110(4):369-82. doi: 10.1007/s00401-005-1055-z. A 5-year-old German-Holstein cow was presented with a swelling of the head which had been present for 3 months. However, in Europe serotype 9 strains also contribute substantially to S. suis-associated invasive diseases of piglets. D-30559 Hannover, Germany e-mail: Send e-mail . In addition, in this plaque type, CD44 is expressed on the cell membrane of perivascular mononuclear cells. 2016 Jul;11:941-54. doi: 10.2217/fmb-2016-0028. Kock C, Beineke A, Seitz M, Ganter M, Waldmann KH, Valentin-Weigand P, Baums CG. Bibliografische Informationen der Deutschen Bibliothek Die Deutsche Bibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; Detaillierte bibliografische Da 2006 Jun 15;115(1-3):117-27. doi: 10.1016/j.vetmic.2005.12.013. vet.) In summary, CD44 and MMPs might be associated with the onset of demyelination and may interact to initiate ECM disturbances. 2003 Nov;106(5):486-94. doi: 10.1007/s00401-003-0754-6. Aerial photography: Department of Pathology. Rieckmann K, Pendzialek SM, Vahlenkamp T, Baums CG. G. Trautwein. in northwestern Madagasca. In the chronic phase, it is conceivable that a MMP-TIMP imbalance may be the motor for lesion progression with a simultaneous influx of CD44-positive activated immune cells. Epub 2017 Nov 28. 2010 Mar;18(3):124-31. doi: 10.1016/j.tim.2009.12.003. … Epub 2006 Jan 20. Donhauser & Schöneberger, Bingen am Rhein, Germany. Epub 2010 Jan 12. Stiftung Tierärztliche Hochschule Hannover. Would you like email updates of new search results? Institut für Pathologie, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D‐3000 Hannover 1Search for more papers by this author. Epub 2018 May 21. (1)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, D-30173 Hannover, Germany. Institut für Mikrobiologie und Tierseucben Direktor: Prof. Dr. W. Bisping der Tierärztlichen Hochschule Hannover Tierärztliche Hochschule, 3 Hannover, Bischofsholer Damm 15. Heredity (Edinb). : 0511 / 953-8621 , 0511 / 953-8664 Diagnostik-Sprechstunden: Mo. The program is subdivided into different seminars (modules) and receives support from speakers from Pharmaceutical and Chemical companies mainly located in Germany. See 3 photos and 3 tips from 80 visitors to Tierärztliche Hochschule Hannover. Gutachter: Univ.-Prof. Marion Hewicker-Trautwein und PD Dr. med. Stiftung Tierärztliche Hochschule Hannover. Institut für Pathologie, Tierärztliche Hochschule Hannover, FRG. Office: Phone: 0049-(0)511- 953-8621; 0049-(0)511-953-8664 Fax: 0049-(0)511-953-8675 Diagnostic service section - consultation hours: Monday – Friday from 2.30 pm – 4.30 pm; phone: 0049-(0)511-953-8622 Aerial photography: Department of Pathology. 2015 Mar 30;10(3):e0121586. Fittipaldi N, Fuller TE, Teel JF, Wilson TL, Wolfram TJ, Lowery DE, Gottschalk M. Vet Microbiol. Institut für Pathologie, Tierärztliche Hochschule Hannover, Bünteweg 17, D‐3000 Hannover 71, Germany . Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis. 2016 Apr 4;11(4):e0152675. Virulence-associated gene profiling of Streptococcus suis isolates by PCR. Zusammenfassung. Institute of Microbiology and Infectious Diseases of Animals, School of Veterinary Medicine, Hannover, Germany. Hennig-Pauka I, Imker R, Mayer L, Brügmann M, Werckenthin C, Weber H, Menrath A, de Buhr N. Pathogens. Due to the central nervous system (CNS) tropism of the virus and associated neuropathological changes, demyelinating canine distemper encephalitis (CDE) represents a relevant model for human demyelinating diseases like multiple sclerosis. R. Müller-Peddinghaus . Abstract; Full Text; References Buy Article Permissions and Reprints. Clipboard, Search History, and several other advanced features are temporarily unavailable. TiHo Hannover - Institut für Pathologie Toxicologic Pathology Training Program A comprehensive Toxicologic Pathology Program is offered within the residency program of the TiHo. Prevention and treatment information (HHS). Gregor Warnecke 2. Comparative mRNA and miRNA expression in European mouflon (Ovis musimon) and sheep (Ovis aries) provides novel insights into the genetic mechanisms for female reproductive success. Epub 2008 Oct 4. Ziel dieser Arbeit war es, festzustellen, ob und wann eine PCV 2-Infektion vor 1998, dem Jahr des erstmaligen Nachweises von PCV 2 in Deutschland, im Sektionsmaterial des Instituts für Pathologie der Stiftung Tierärztliche Hochschule Hannover aufgetreten ist. Project: Effects of habitat fragmentation on parasite communities in mouse lemurs (Microcebus spp.)